Glycobiology in Personalized Medicine


The human gut hosts trillions of bacteria that directly influence human health. The majority of gut microbiota play an important role in nutrition by metabolizing host-indigestible complex glycans into short-chain fatty acids. Growth of the mesh-like peptidoglycan (PG) sacculus located between the bacterial inner and outer membranes (OM) is tightly regulated to ensure cellular integrity, maintain cell shape, and orchestrate division. Asparagine (N)-linked protein glycosylation is a ubiquitous co- and post-translational modification which can alter the biological function of proteins and consequently affects the development, growth, and physiology of organisms. In mammals, complex N-glycans are involved in different cellular processes including molecular recognition and signalling events


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