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Minghua Hu

Minghua Hu

Infinitus (China) Company Ltd., China

Title: Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice

Biography

Biography: Minghua Hu

Abstract

Fungal polysaccharides have been shown broad spectrum of biological activities, including anti-inflammatory, ant-oxidative and improve immunity. However, oral administration of fungal polysaccharides for rendering the conventional vaccine against influenza virus has been reported rarely. Here, we investigated the potential of fungal polysaccharides enhancing the influenza vaccine efficacy in a mouse model. Mice were immunized with inactivated H1N1 (A/PR8/1934) influenza vaccine combined with oral polysaccharides lentinan, tremellan, pachymaran, and a mixture of the three. The results showed that mice in the polysaccharides/vaccine groups had reduced morbidity, improved viral clearance, and recovered faster than the mice receiving the conventional vaccine only after infection. This effect could be attributed to the increased levels of virus-specific serum antibody IgG and decreased levels of inflammatory cytokine IFN-γ in the lung tissue. Our finding suggests that taking fungal polysaccharides orally might be useful for improving the efficacy of conventional inactive influenza vaccines.

References

1.            Luo Xia,Minghua Hu ,et(2016)Different impacts of polysaccharides from Chinese materia medica on T-cell subsets in immuno-suppressed mice . Prac J Med&Pharm．2016,07:621-624.

2.            Xiangliang Deng, Zhonghua Ma, Xiaoping Lai, Minghua Hu,et(2016)Rhizoma dioscoreae polysaccharide promotes M1 macrophage polarization in mice.IMMUNOLOGICAL JOURNAL 2016,12:1019-1023.

3.            LUO Xia,MA Zhonghua,HU Minghua,et(2016)Effects of compound polysaccharide on cellular immunity in mice.CHINESE JOUï¼²NAL OF FOOD HYGIENE 2016,02:186-191.

4.            REN Wenkang,HU Minghua,YIN Xiquan,et(2016)Effect of Cyclocarya paliurus（Batal.）Ijinsk Aqueous Extracts on Improving Traditional Chinese Medical Symptoms and Immune Function of Type 2 Diabetic Mellitus Rats with Yin Deficiency Generating Intrinsic Heat Syndrome.Journal of Guangzhou University of Traditional Chinese Medicine 2016,06:851-855.

5.            Minghua Hu,et(2012)Comparison of Content of the Water-Soluble Polysaccharide Included in Poria Cocos from Different Habitat and Specification.China Pharmaceuticals 2012,07:10-12.