Joon Kim
Korea University, Korea
Title: Ribosomal protein S3 secreted from cancer cell lines is N-glycosylated
Biography
Biography: Joon Kim
Abstract
Ribosomal protein S3(rpS3) is a component of the 40S ribosomal small subunit but has multiple other extra-ribosomal functions like apoptosis, cell cycle control, DNA repair etc. It has a DNA repair endonuclease activity which is related with various cancers. Recently, we have discovered that this protein is secreted only from various cancer cell lines as a homodimer but not in normal cells. We also confirmed that rpS3 is secreted more into media from the more invasive cancer cell lines. Presently we confirmed that the secreted protein is glycosylated at the Asn 165 residue and point mutation on this site is defective for the secretion. The secretion pathway turned out to be a ER-Golgi dependent pathway. We propose that glysosylated rpS3 could be used as a useful cancer marker.
