Jan Tkac
Slovak Academy of Sciences, Slovakia
Title: Integration of nanotechnology into glycomics: Construction and application of glycan and lectin biosensors
Biography
Biography: Jan Tkac
Abstract
Integration of nanotechnology into the field of glycomics can address current limitations of fluorescent glycan and lectin microarrays [1,2]. Moreover, label-free transducing schemes especially when working in an ultrasensitive fashion can be applied in a reliable detection of low abundant disease biomarkers [3-5]. For example, electrochemical impedance spectroscopy applied in our studies allows to detect analyte molecules down to a single molecule level (i.e. aM level) if immobilization architecture of ligands (lectins or glycans) is controlled at nanoscale [6-8]. Utilization of such devices in serological glycoprofile of samples from people having some diseases, in analysis of cancer biomarkers, cancer cell lines and viruses will be discussed. Acknowledgement: The financial support from the Slovak research and development agency APVV 0282-11 is acknowledged. The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP/2007-2013)/ERC Grant Agreement No. 311532 and from the European Union’s Seventh Framework Program for research, technological development and demonstration under grant agreement No. 317420.
