Cecilia H. Marzabadi
Seton Hall University, USA
Title: Novel carbohydrate-based ligands with immunostimulatory properties
Biography
Biography: Cecilia H. Marzabadi
Abstract
We are interested in the synthesis and biological evaluation of new carbohydrate structures with the capacity to act as immunomodulators. Towards these ends we have synthesized molecules as mimics of capsular saccharides. These highly simplified saccharide structures have been shown to act as TLR4 agonists and to elicit the secretion of proinflammatory cytokines at concentrations lower than the known agonist, E. coli lipopolysaccharide. In this presentation, we will discuss the synthetic efforts towards a lead compound and the preliminary biological data obtained for this compound. Efforts to elucidate the mechanism of action of this molecule will be discussed.