Ajiloseda Charles Adeniyi
Adyghe State University, Russia
Title: Cytokine gene polymorphism (IL-17A G197A, TNF-alpha G308A, IL-6 C174G) and human major histocompatibility complex (HLA DRB1) specificities control in bronchial asthma
Biography
Biography: Ajiloseda Charles Adeniyi
Abstract
In the development of non-specific resistance in an immune system, important role belongs to mediators of the said immune system; the pro-inflammatory cytokines which in turn activates expression of class II HLA-DRB1 on antigen presenting cells (APC) that implement specific immunity. The pathologies of many infectious, autoimmune and malignant diseases are influenced by the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T cells. With TLR (Toll-like receptor) on dendritic cells recognizing PAMP (pathogen-associated molecular patterns); antigens that trigger a cascade of specific antibody and cytokine. Many studies have examined the relationship between cytokine gene polymorphism, cytokine gene expression in vitro and the susceptibility to and clinical severity of diseases. Our study here tends to and as extensively as possible expose the relationship of cytokines gene polymorphism and Human Major Histocompatibility complex with respect to bronchial asthma.