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Scientific Program

2^nd Glycobiology World Congress, will be organized around the theme “Glycobiology: The bitter side of the sweet world”

Glycobiology 2016 is comprised of 10 tracks and 6 sessions designed to offer comprehensive sessions that address current issues in Glycobiology 2016.

Submit your abstract to any of the mentioned tracks. All related abstracts are accepted.

Track 1:Evolution of Glycan Diversity

Glycans are saccharides that can be attached to a wide variety of biological molecules through an enzymatic process called glycosylation to augment their function. Of the four fundamental building blocks of life, proteins, carbohydrates (glycans), lipids and nucleic acids, glycans have received the least attention from researchers. Glycans are found in archaea, bacteria and eukaryotes, and their diverse functions contribute to physical and structural integrity, extracellular matrix formation, signal transduction, protein folding and information exchange between cells (and pathogens). Glycans are the predominant molecule on the cell surface and serve as the first point of contact between a cell and other cells, the extracellular matrix and pathogens. The heightened evolutionary pressure of being at the front lines of cellular collaboration and conflict most likely led to the diversification of glycans. Glyco-epitope diversity enhances the role of glycans in the group of debilitating and life-shortening disorders known as congenital muscular dystrophy, or CMD. Both membrane proteins and the ECM are highly glycosylated, and O-glycans are essential for proper ECM function and communication between cells and the ECM. Several Glycoepitomics forms of CMD are known to result from dysfunctional O-glycosylation of membrane and ECM proteins; however, one-third of CMDs arise from an unknown genetic etiology.

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

6th International Conference on Bioinformatics, March 29-30, 2016 Valencia, Spain; International Conference on Structural Biology, June 23-24, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Baltimore, USA; International Conference on Nucleic Acids, August 04-06, 2016 Seattle, USA 7th International Conference and Expo on Proteomics, October 24-26, 2016 Rome, Italy; International Conference on Obesity & Chronic Diseases, July 25-27, 2016 Las Vegas USA; International Conference on New Therapeutics for Diabetes and Obesity, April 17-20, 2016 La Jolla, USA; Conference on Plasma Spectrochemistry, January 10-16, 2016 Tucson, USA; Euro Fed Lipid Congress, September 18-21, 2016 Gent, Belgium; Conference on Obesity and Adipose Tissue Biology, February 15-19, 2016 Banff, Canada

Track 1-1Glycoepitomics
Track 1-2Glycan structural modelling
Track 1-3Biochemical analysis of lipids & proteins
Track 1-4Comparative Glycomics
Track 1-5Synthesis systems of glycans
Track 1-6Glyco-epitope Diversity

Track 2:Glycan Catabolism and Systemic Physiology

The human gut hosts trillions of bacteria that directly influence human health. The majority of gut microbiota play an important role in nutrition by metabolizing host-indigestible complex glycans into short-chain fatty acids. Growth of the mesh-like peptidoglycan (PG) sacculus located between the bacterial inner and outer membranes (OM) is tightly regulated to ensure cellular integrity, maintain cell shape, and orchestrate division. Cytoskeletal elements direct placement and activity of PG synthases from inside the cell, but precise spatiotemporal control over this process is poorly understood. Glycan catabolism contains metabolic pathway maps for glycans. Some of them contain an alternative representation of glycan biosynthesis or degradation, called the glycan structure map.

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 2-1Gene expression regulation
Track 2-2Metabolic pathways and analysis
Track 2-3Peptidoglycan synthesis and regulation
Track 2-4Glycans in human physiological mechanisms
Track 2-5Cell signalling analysis

Track 3:Glycans in Diseases and Therapeutics

The beginning of the 20(th) century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest in the therapeutic applications of glycans. Essentials of glycobiology review focuses on advances within the past decade that are bringing glycan-based treatments back to the forefront of medicine and the technologies that are driving these efforts. These include the use of glycans themselves as therapeutic molecules as well as engineering protein and cell surface glycans to suit clinical applications to that of databases providing glycoenzyme data. Glycan therapeutics offer a rich and promising frontier for developments in the academic, biopharmaceutical, and medical fields.

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

6th International Conference on Bioinformatics, March 29-30, 2016 Valencia, Spain; International Conference on Structural Biology, June 23-24, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Baltimore, USA; International Conference on Nucleic Acids, August 04-06, 2016 Seattle, USA 7th International Conference and Expo on Proteomics, October 24-26, 2016 Rome, Italy; International Conference on Obesity & Chronic Diseases, July 25-27, 2016 Las Vegas USA; International Conference on New Therapeutics for Diabetes and Obesity, April 17-20, 2016 La Jolla, USA; Conference on Plasma Spectrochemistry. January 10-16, 2016 Tucson, USA; Euro Fed Lipid Congress, September 18-21, 2016 Gent, Belgium; Conference on Obesity and Adipose Tissue Biology, February 15-19, 2016 Banff, Canada

Track 3-1Glycomedicine
Track 3-2Transfusion Medicine
Track 3-3Reperfusion injury
Track 3-4Cancer associated coagulopathies
Track 3-5Hepato cellular Glycosylation
Track 3-6Cancer Therapeutics
Track 3-7Congenital disorders of Glycosylation (CDG)
Track 3-8Cardiovascular Diseases
Track 3-9Cancer Biomarkers

Track 4:Glycobiology: Its Role In Human Health

Glycobiology and Glycochemistry are the two main intertwined areas of Glycosciences, dealing with various aspects of glycans, including carbohydrate structure, biochemistry, biological functions and applications. This is necessary in order to sustain and advance the identification of key glycobiological aspects and the application of glycans and glycoengineering strategies in the design of novel therapies to improve human health. The glycans (carbohydrates) form a diverse group of biomolecules which play active parts in most physiological processes. The field of structural glycobiology concerns the structures of the glycans themselves, the proteins which interact with them and the nature of the interactions between the two. Drug targeting is important for our understanding of human health and disease, and for development of new therapeutic strategies.

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 4-1Biosynthesis of disease related carbohydrate antigens
Track 4-2Glycoproteome analysis
Track 4-3Glycoprotein folding and routing
Track 4-4Drug targeting
Track 4-5Anti-adhension therapy

Track 5:Glycobiology & Biotechnology

Glycans are components of many biotherapeutic agents, ranging from natural products to molecules based on rational design to recombinant glycoproteins. The glycan components of these agents can be important determinants of their biological activity and therapeutic efficacy. Biochemistry and Glycobiology involves a multidisciplinary study of carbohydrate-binding proteins (lectins) and some other plant proteins that are capable of interacting with endogenous or foreign (macro) molecules. The emphasis of the research is on protein-carbohydrate interaction and their involvement in signalling processes in plants or in plant protection. Based on the generated fundamental knowledge novel strategies are being developed to protect crop plants against pests and diseases.

The key drivers for this glycobiology market are the rising R&D expenditure by pharmaceutical and biotech companies, and increasing public and private funding for proteomics and glycobiology research. According to the World Bank, funding for research and development activities in Asia was about $158.94 billion in 2001 and increased to $329.31 billion in 2010. Similarly, in the U.S., overall funding for research and development was about $291.77 billion in 2001, which increased to $428.94 billion in 2010. Increased funding activities are expected to positively impact the growth of the glycobiology enzymes, instruments, kits, and reagents market.

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 5-1Glyconutrients
Track 5-2Microbial glycobiology
Track 5-3Structural analysis of glyco-lipids
Track 5-4Glycoproteomics
Track 5-5Glycosylation disorders
Track 5-6Glycoprotein modelling
Track 5-7Proteoglycan signaling
Track 5-8Vaccine Development
Track 5-9Plant Biotechnology
Track 5-10Glycosylation synthesis of plant proteins

Track 6:Glycomics and Bioinformatics

Glycomics the scientific attempt to characterize and study carbohydrates, is a rapidly emerging branch of science, for which informatics is just beginning. Glycomics requires sophisticated algorithmic approaches. Several algorithms and models have been developed for glycobiology research in the past several years. The development and use of informatics tools and databases for glycobiology and glycomics research has increased considerably in recent years. However, the general development in this field can still be considered as being in its infancy when compared to the genomics and proteomics areas. In terms of bioinformatics in glycobiology, there are several paths of research that are currently in progress. The development of algorithms and software tools for interpretation of glycans to reliably support the characterization of glycan structures for high-throughput applications is the most immediate demand of the glycomics community.

The global glycomics market was valued at $512.38 million in 2014 and poised to grow at a CAGR of 12.62% between 2012 and 2019, to reach $928.11 million in 2019. The rapid increase in research and development expenditure by pharmaceutical and biotech companies, and increased funding in proteomics and glycobiology research will be the two most important growth drivers for this market in the forecast period (2012–2019).

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 6-1Gene expression profiling
Track 6-2Databases providing Glycoenzyme data
Track 6-3Bioinformatics tools for protein analysis
Track 6-4Computational biomodelling
Track 6-5Molecular Modelling
Track 6-6Microarray Gene Expression
Track 6-7Applications of genomics and bioinformatics

Track 7:Classification of Glycan Binding Proteins

Glycans can mediate a wide variety of biological roles by virtue of their mass, shape, charge, or other physical properties. However, many of their more specific biological roles are mediated via recognition by GBPs. Nature appears to have taken full advantage of the vast diversity of glycans expressed in organisms by evolving protein modules to recognize discrete glycans that mediate specific physiological or pathological processes. Excluding glycan-specific antibodies, GBPs broadly into two major groups such as lectins and glycosaminoglycan-binding proteins. Most lectins are members of families with defined “carbohydrate-recognition domains” (CRDs) that apparently evolved from shared ancestral genes, often retaining specific features of primary amino acid sequence or three-dimensional structure. Thus, new family members can be identified by searching protein sequence or structural databases. The natural ligands for most lectins are typically complex glycoconjugates that carry clustered arrays of the cognate carbohydrate or unique glycan structures, thus cooperating with clustered lectin-binding sites to generate high-avidity binding, which is further enhanced by mass transport effects (high local concentrations of ligands).

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 7-1Carbohydrate recognition domains
Track 7-2Glycan Array modelling structure
Track 7-3Sugar binding proteins
Track 7-4Protein trafficking
Track 7-5Ligand profiling
Track 7-6Glycosaminoglycan binding proteins

Track 8:Synthesis and Biological Role of Glycans

As with other major classes of macromolecules, the biological roles of glycans span the spectrum from those that appear to be relatively subtle, to those that are crucial for the development, growth, functioning, or survival of the organism that synthesizes them. The biological roles of glycans can be divided into two broad categories: (1) the structural and modulatory properties of glycans and (2) the specific recognition of glycans by other molecules most commonly, glycan-binding proteins (GBPs). The biological consequences of altering glycosylation in various systems seem to be highly variable and unpredictable. A given glycan can have different roles in different tissues or at different times in development (organism-intrinsic functions) or in different environmental contexts (organism-extrinsic functions). Approaches taken to understand the biological roles of glycans include the prevention of initial glycosylation, prevention of glycan chain elongation, alteration of glycan processing, enzymatic or chemical deglycosylation of completed chains, genetic elimination of glycosylation sites, and the study of naturally occurring genetic variants and mutants in glycosylation.

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 8-1Specific intra and extra cellular ligand interactions
Track 8-2Design, synthesis and evaluation of iminosugar
Track 8-3Formation and synthesis of glycan chains
Track 8-4Large scale production of glycoproteins
Track 8-5Protein Glycosylation

Track 9:Glyco Immunology

Carbohydrates were prominent in the early history of immunology in defining the identity of antigens recognized by antibodies. In addition, the ability of antibodies to specifically recognize glycans was exploited in studies defining the size of the antigen-binding site. Nevertheless, for many decades following these early discoveries the broader potential importance of carbohydrates in both innate and adaptive immune responses was largely overlooked. However, times are changing and glycobiologists and immunologists are now collaborating extensively to explore this very fertile area of immunobiology. Numerous carbohydrate-binding proteins, or lectins, have been identified on the surfaces of immune cells. Interactions of lectins with glycans usually require several monosaccharide moieties presented in the correct conformation for high-affinity binding. Modification of proteins and lipids by glycosylation is a highly regulated process resulting in a diverse repertoire of glycan structures.

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 9-1Glycoengineering of immunogens
Track 9-2Glycoconjugate vaccines
Track 9-3Glycan immunotherapies
Track 9-4Glycan sensing
Track 9-5Carbohydrate aromatic interactions
Track 9-6Impact of glycans on antigen-antibody interactions

Track 10:Glycans in Drug Design

Glycans are at the center of many disorders and diseases sparking the possibility of exploiting them for therapeutic and diagnostic purposes. There are many biochemical pathways and diseases in which glycans are intricately involved. Gaging the vast potential and the promise that glycobiology holds, many pharma and biotech companies have already started allocating their R&D budget to it. Presently, with our drug arsenal fast depleting against drug resistant and mutant pathogens, glycobiology hold an untapped source of new candidate drugs.

The rapid increase in research and development expenditure by pharmaceutical and biotech companies, and increased funding in proteomics and glycobiology research will be the two most important growth drivers for this market in the forecast period (2012–2019).

Relevant Conferences:Glycobiology Conferences | Biochemistry Conferences

Track 10-1Drug interaction in cellular networking
Track 10-2Proteome mapping
Track 10-3Biomarkers in drug design
Track 10-4Proteinâ€“Ligand and Proteinâ€“Protein interactions
Track 10-5Screening and drug design
Track 10-6Drug delivery using Nanotechnology

2^nd Glycobiology World Congress August 29-31,2016 Atlanta, USA

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